The AASHTO Guide Specifications for Structural Design with Ultra-High Performance Concrete, First Edition (2024), provide design provisions for bridge and ancillary structures built with ultra-high performance concrete. Early articles establish the scope, design philosophy, loads and load combinations, and limitations on the use of the specifications. Sections on limit states and design methodologies set out service, strength, and extreme event assumptions for UHPC members. Design provisions follow for flexural and axial force effects and for shear and torsion in B-regions. Reinforcement requirements are addressed, including transverse reinforcement for compression and flexural members, shrinkage and temperature reinforcement, and development and splices of reinforcement. The specifications are intended for engineers designing UHPC structural components and connections for highway bridges.